Critical Care Obstetrics and Gynecology

Vitamin D3 Administration in PCO Obese Patients: Effect on the Follicular Fluid Level of Vitamin D3 and Pregnancy Outcome in ICSI

Aim of the work: To study the effect of vitamin D3 administration on the follicular fluid level of vitamin D3 and pregnancy outcome in obese polycystic ovary (PCO) patients undergo intra-cytoplasmic sperm injection (ICSI).
Study type, time and site: Prospective cohort study from January 2014 to March 2015 at private in-vitro fertilization (IVF) center.
Patients and methods: Study participants were ninety eight obese PCO women aged 20-39 years who were candidates for ICSI. They were divided into two groups: Group A: Patients who went directly to ICSI and Group B; patients who received 1000 IU of Vitamin D3 twice daily for 3 months prior to IVF. Standard long agonist protocol was used for all patients and serum Vitamin D3 level was estimated for each of them. The main outcome of the study was the pregnancy rate in relation to the vitamin D3 level.
Results: Serum Vitamin D3 levels in Group B after treatment were significantly higher than before treatment (p=0.0002). Strong positive correlation (r=0.859, p<0.001) was found between serum vitamin D3 level and follicular fluid vitamin D level at the time of ICSI procedure. There was a 33% more chance of achieving pregnancy after receiving vitamin D3 treatment.
Conclusion: Oral administration of vitamin D before ICSI in obese PCO patients improved the serum and follicular fluid vitamin D level and yielded better pregnancy rate.

Author(s):

Ahmed S El-Halwagy, Ayman A El-Dorf, Walid M Ataalla and Adel A Al-Gergawy

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